The use of acetylation to improve the performance of hyaluronic acid-based dermal filler

Injectable dermal fillers, which are used for various plastic surgery purposes, experiencing explosive market growth due to increasing interest in appearance management. Hyaluronic acid (HA) hydrogels have been considered an ideal material fillers their high-water retention, biodegradability, and biocompatibility. However, application is limited by shortcomings durability persistence caused rapid enzymatic degradation. Therefore, this study, we introduce acetylated hyaluronic acid-divinyl sulfone (AcHA-DVS) a novel approach improving the physical properties gel retention time of HA. The AcHA-DVS showed significant advantages terms longevity performance as compared HA-DVS hydrogels. These results suggest that our new hydrogel promising biomaterial injectable filler or scaffold tissue engineering.